SO, I guess I'll start off...
I think a deeper economy simulation experience would be nice to see; one that not only affects prices between towns but also population and inventory.
Maybe eventually have towns be able to be besieged, by bandits or random factions, or just towns become entirely abandoned for whatever reason.
It'd be interesting to have looting and ransacking from the NPCS (corpses, unconscious persons, and towns).
I'd also like to see hunger/thirst/sleep being further implemented as well for both npcs and players, though I have a feeling that's planned.
Also, killer chickens with laser eyes.