are ruins and other special locations,one loot and done ?

[tkobo]

or do they respawn loot ?

[Sol Lignum]

They does that upon importing the game. However i don't think loot may respawn without importing.

[swillo]

Most respawn when importing to a new game, however I have seen a couple that hold the status from game to game. Like specific characters that join you squad will not reappear in new imports.

Also there is some randomness to which locations are in each game. So just cause one location was a treasure trove one game. When you import it might be an empty shell the next time. And one that was empty before is now full.

(I'm assuming that was intentional and not just a glich.)

[Murdath]

There is a cannibal tower sought of the cannibal capital, the ramp usually has loot that re-spawns, the second level is full of cannibals but they are easy enough to beat. Loot in boxes doesn't seem to re-spawn.